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Clothiandian

 Clothianidin is an insecticide developed by Takeda Chemical Industries and Bayer AG. Similar to thiamethoxam and imidacloprid, it is a neonicotinoid. Neonicotinoids are a class of insecticides that are chemically similar to nicotine, which has been used as a pesticide since the late 1700s. Clothianidin and other neonicotinoids act on the central nervous system of insects as an agonist of acetylcholine, the neurotransmitter that stimulates nAChR, targeting the same receptor site (AChR) and activating post-synaptic acetylcholine receptors but not inhibiting AChE.

Clothianidin and other neonicotinoids were developed to last longer than nicotine, which is more toxic and which breaks down too quickly in the environment. However, studies published in 2012 show that neonicotinoid dust released at planting time may persist in nearby fields for several years and be taken up into non-target plants, which are then foraged by bees and other insects.[citation needed] Clothianidin is an alternative to organophosphate, carbamate, and pyrethroid pesticides. It poses lower risks to mammals, including humans, when compared to organophosphates and carbamates. It has helped prevent insect pests build up resistance to organophosphate and pyrethroid pesticides.

According to the Environmental Protection Agency (EPA), clothianidin's major risk concern is to nontarget insects (honey bees). Information from standard tests and field studies, as well as incident reports involving other neonicotinoid insecticides (e.g., imidacloprid) suggest the potential for long term toxic risk to honey bees and other beneficial insects.

Partially condensed, Kekulé, skeletal formula

Names

IUPAC name
1-(2-Chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine

Identifiers

CAS Registry Number

210880-92-5 (E

Beilstein Reference

9196326, 8620724 (E)

ChEBI

CHEBI:39178

ChEMBL

ChEMBL259727 

ChemSpider

184723 (E

InChI

Jmol-3D images

Image
Image

KEGG

C18508 

MeSH

Clothianidin

PubChem

213027 (E)

SMILES

Properties

Chemical formula

C6H8ClN5O2S

Molar mass

249.67 g·mol−1

Appearance

Colorless crystals

Density

1.61 g cm−3

Melting point

179 °C (354 °F; 452 K)

Solubility in water

327 mg dm−3 (at 20 °C)

log P

0.732

Acidity (pKa)

7.472

Basicity (pKb)

6.525

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).